ASP
  • COVID
    • INPATIENT >
      • CONSIDERATIONS & LABS
      • PAXLOVID
      • REMDESIVIR
      • OLUMIANT
      • ACTEMRA
      • STEROIDS
      • VTE
    • OUTPATIENT
  • Education
    • Bugs & Tips
    • Agents & Spectra
  • Guidelines
    • By Infection Type
    • Surgical Prophylaxis >
      • By Procedure
      • Dosing Guide
  • Formulary
  • Antibiogram
    • 2023 Inpatient
    • 2023 Outpatient
    • 2022 Inpatient
    • 2022 Outpatient
    • 2021 Inpatient
    • 2021 Outpatient
    • 2020 Inpatient
    • 2019 Inpatient
    • 2019 Outpatient
  • About
    • ASP Program
    • Stats & Data >
      • Recommendations
      • Pharmacy Data
      • MDR ORGANISMS
      • DDD/DOT
    • Contact

hAEMOPHILUS INFLUENZAE

LAB WORK​
  • G(-), encapsulated organism (six different capsules; type "b" crucial for virulence, allows organism to enter the bloodsteam, hence abbreviation "HIB", Haemophilus infleunza type b)

TREATMENT​
  • ​Divided according to whether this is HIB or other HI ("non-typeable")
  • A third of HI strains produce beta lactamase, so aminopenicillins like ampicillin or amoxicillin should only be used if sensitivity is confirmed!
    • ​Non-Typeable HI (typically cause mucosal infections, OM, COPD exacerbations, sinusitis, conjunctivitis, CAP)
      • ​Mild (Note: the agents below also cover Strep. pneumo and Moraxella)
        • ​Augmentin
        • Respiratory FQ (levofloxacin, moxifloxacin)
        • Macrolides (azithromycin, clarithromycin)
        • Extended spectrum oral cephalosporins (cefixime, cefpodoxime)
      • Severe
        • ​Rocephin
        • Unasyn
        • Fluoroquinolones IV
        • Azithromycin IV
    • HI Type B  (associated with invasive infections, meningitis, epiglottitis, PNA, bacteremia, septic arthritis)
      • ​First line: Ceftriaxone or Cefotaxime
        • ​Duration: 7-10 days, continue treatment until afebrile and asymptomatic for 3-5 days
      • ​For meningitis, adding dexamethasone course x 4 days associated with decreased incidence of neurological symptoms in children
        • ​If administering, give 15-20 minutes before FIRST dose of antibiotic 

​CLINICAL NOTES​
  • Chemoprophylaxis
    • In absence of immunization, household contacts of individuals with invasive HIB who are under 4 years of age are at increased risk, so prophylaxis with rifampin x 4 days is recommended in 2 groups within 7 days of exposure:
      • For all household members including adults (except for pregnant women) where there's been contact by a member under 4 years of age and whose immunization status with the HIB vaccine is incomplete OR an immunocompromised child of any age.
      • For all attendees and personnel at daycare centers/nurseries when 2 or more cases of invasive HIB have occurred within 60 days if incompletely immunized children attend the facility
  • Immunization for HIB is available, conjugate HIB vaccines (ACTHIB, PedvaxHIB) which all children should be vaccinated with (series) starting at 2 months of age.
  • COVID
    • INPATIENT >
      • CONSIDERATIONS & LABS
      • PAXLOVID
      • REMDESIVIR
      • OLUMIANT
      • ACTEMRA
      • STEROIDS
      • VTE
    • OUTPATIENT
  • Education
    • Bugs & Tips
    • Agents & Spectra
  • Guidelines
    • By Infection Type
    • Surgical Prophylaxis >
      • By Procedure
      • Dosing Guide
  • Formulary
  • Antibiogram
    • 2023 Inpatient
    • 2023 Outpatient
    • 2022 Inpatient
    • 2022 Outpatient
    • 2021 Inpatient
    • 2021 Outpatient
    • 2020 Inpatient
    • 2019 Inpatient
    • 2019 Outpatient
  • About
    • ASP Program
    • Stats & Data >
      • Recommendations
      • Pharmacy Data
      • MDR ORGANISMS
      • DDD/DOT
    • Contact